High-speed and crack-free direct-writing of microchannels on glass by an IR femtosecond laser

Fabrication of high-resolution 3D structures with laser radiation on the surface of brittle materials has always been a challenging task. Even with femtosecond laser machining, micro-cracks and edge chipping occur. In order to evaluate processing modes optimal both in quality and productivity, we investigated high-speed (50 kHz) femtosecond laser processing of BK7 glass with the use of design of experiments and regression analysis. An automated inspection technique was developed to extract quality characteristics of test-objects. A regression model was obtained appropriate to fabricate microchannels with a predefined depth in the range of 1–30 µm with average accuracy of 5%. It was found that high quality machining modes are in the range of 0.91–2.27 µJ energy pulses, overlap of 53–62%, three and more number of passes. A material removal rate higher than 0.3 mm³/min was reached and microfluidic structures were formed based on data obtained.     

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利用SOLPS和DINA程序,对偏滤器的数值模拟进行综合研究。结合HL-2M装置,针对偏滤器的结构优化、脱靶物理过程、偏滤器送气与抽气、垂直位移事件(VDE)等问题进行了模拟研究。分析了偏滤器靶板位形以及脱靶对偏滤器靶板热载荷的影响,研究了偏滤器的送气位置、送气速率、抽气速率等因素对于偏滤器性能的影响;同时,利用DINA程序对HL-2M装置的VDE过程进行了预测分析,并给出了HL-2M装置发生VDE过程的等离子体电流剖面变化,从而为HL-2M装置的偏滤器结构设计和分析提供输入数据。     

Partial least squares model and design of experiments toward the analysis of the metabolome of Jatropha gossypifolia leaves: Extraction and chromatographic fingerprint optimization

A major challenge in metabolomic studies is how to extract and analyze an entire metabolome. So far, no single method was able to clearly complete this task in an efficient and reproducible way. In this work we proposed a sequential strategy for the extraction and chromatographic separation of metabolites from leaves Jatropha gossypifolia using a design of experiments and partial least square model. The effect of 14 different solvents on extraction process was evaluated and an optimized separation condition on liquid chromatography was estimated considering mobile phase composition and analysis time. The initial conditions of extraction using methanol and separation in 30 min between 5 and 100% water/methanol (1:1 v/v) with 0.1% of acetic acid, 20 μL sample volume, 3.0 mL min^?1 flow rate and 25°C column temperature led to 107 chromatographic peaks. After the optimization strategy using i‐propanol/chloroform (1:1 v/v) for extraction, linear gradient elution of 60 min between 5 and 100% water/(acetonitrile/methanol 68:32 v/v with 0.1% of acetic acid), 30 μL sample volume, 2.0 mL min^?1 flow rate, and 30°C column temperature, we detected 140 chromatographic peaks, 30.84% more peaks compared to initial method. This is a reliable strategy using a limited number of experiments for metabolomics protocols.     

Robust simulation with a base environmental scenario

In the design of a system, the comparison of possible solutions using simulation is generally performed with fixed environmental conditions. In practice, however, unexpected changes can occur for example in the part mix of a manufacturing facility or in the customer demand. Such changes, which are considered as modifications in environmental factors, can impact the system response. As a consequence, a solution A that is better than B for a given environment, can yield poorer performance than B for another environment. Therefore, we are interested in robust simulation studies, which aim at taking into account several possible environments. In methods based on Taguchi’s principles, no distinction is made between these environments in the robustness computation. In the suggested heuristic approach, we focus on problems where a particular environment is expected when the system will be in operation (the others being unexpected environments). This particular environment will be considered in the study as a “base environmental scenario”. The robustness of a solution of the design problem is computed as an approximate measure of what will be saved or lost if the environment becomes the unexpected. Reference curves are suggested to allow these solutions to be empirically compared in accordance with the decision-maker’s requirements. A simplified example is provided. The results are different from those obtained using a signal to noise ratio, which is typically used in Taguchian approaches.     

Teacher and students’ joint production of a reversible fraction conception

Within a constructivist perspective, I conducted a teaching experiment with two fourth graders to study how a teacher and students can jointly produce the reversible fraction conception. Ongoing and retrospective analysis of the data revealed the non-trivial process by which students can abstract multiplicative reasoning about fractions. The study articulates a conception in a developmental sequence of iteration-based fraction conceptions and the teacher’s role in fostering such a conception in students.     

红外成象分离双透镜系统设计

本文介绍红外成象大孔径、大视场物镜的设计原理及象质评价方法,导出了求解初始结构参数的象差方程,给出了设计实例及象质评价结果。     

用于ICP－AES双套可拆式循环喷雾系统

研制了一种用于ＩＣＰ－ＡＥＳ小体积样品分析的循环喷雾系统，该系统是将同心喷雾器垂直安装在可拆式双套筒雾室中，具有测定精密度好，检出限低，样品溶波消耗少，喷雾系统易于清洗等特点。     

一项从CAA到CAD的工作 ～正交优化法与SPICE相结合

电子电路的计算机辅助设计方法是促进电子技术发展的一种有效工具。本文介绍如何将行之有效的正交优化法与国际盛行的模拟电子电路的分析程序ＳＰＩＣＥ相结合，形成了ＡＣＯＤ软件，将ＣＡＡ扩展为ＣＡＤ。